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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2f2c  sequence information (FASTA format)   
RELATED PDB ID2euf
DescriptorCyclin homolog, Cell division protein kinase 6 (E.C.2.7.1.37)
TitleX-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol
Functional KeywordsSmall molecule inhibitor bound between N-terminal and C-terminal domain of kinase, CELL CYCLE/TRANSFERASE COMPLEX
Biological sourceHerpesvirus saimiri (strain 11),Homo sapiens (human) (the details in Structural Details Page)
Organ source [UNP - Q00534] Brain
Total number of polymer chains2
Total molecular weight64310.3 (the details in Structural Details Page)
AuthorsSchulze-Gahmen, U , Lu, H. (deposition date : 2005-11-16, release date : 2006-06-13)
Primary citationLu, H. , Schulze-Gahmen, U.
Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49:3826 - 3831, 2006.(PubMed : 16789739)  (DOI: 10.1021/jm0600388)
Experimental methodX-RAY DIFFRACTION ( 2.80[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q01043, Q00534 ) , eF-site , PISA