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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2fd6  sequence information (FASTA format)   
RELATED PDB ID2fat
DescriptorUrokinase-type plasminogen activator (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B], L chain of Fab of ATN-615 anti-uPAR antibody , H chain of Fab of ATN-615 anti-uPAR antibody , Urokinase plasminogen activator surface receptor
TitleStructure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A
Functional KeywordsuPAR, ATF, ATN-615 antibody, Fab, crystal structure, ternary complex, IMMUNE SYSTEM, HYDROLASE
Biological sourceHomo sapiens (human) ,Mus musculus (house mouse) (the details in Structural Details Page)
Cellular location [UNP - P00749] Secreted
[UNP - Q03405] Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 2: Secreted (Probable)
Organ source [UNP - P00749] Lung
[UNP - Q52L64] Mammary tumor. WAP-TGF alpha model. 7 months old
[UNP - Q4V9V8] Mammary gland
[UNP - Q03405] Placenta
[UNP - Q03405] Skin
[UNP - Q03405] Lung cancer
Total number of polymer chains5
Total molecular weight92850.3 (the details in Structural Details Page)
AuthorsHuang, M. , Huai, Q. , Li, Y. (deposition date : 2005-12-13, release date : 2006-02-21)
Primary citationHuai, Q. , Mazar, A.P. , Kuo, A. , Parry, G.C. , Shaw, D.E. , Callahan, J. , Li, Y. , Yuan, C. , Bian, C. , Chen, L. , Furie, B. , Furie, B.C. , Cines, D.B. , Huang, M.
Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311:656 - 659, 2006.(PubMed : 16456079)  (DOI: 10.1126/science.1121143)
Experimental methodX-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , eF-site , KEGG ( EC 3.4.21.73 ) , PISA