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X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
Functional Keywords
HIV Protease, drug resistance, enzyme kinetics, sequence conservation, protein structure, HYDROLASE
Foulkes, J.E. , Prabu-Jeyabalan, M. , Cooper, D. , Schiffer, C.A.
(deposition date : 2005-12-22, release date : 2006-11-07)
Primary citation
Foulkes, J.E. , Prabu-Jeyabalan, M. , Cooper, D. , Henderson, G.J. , Harris, J. , Swanstrom, R. , Schiffer, C.A. Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity. J.Virol.,
80:6906 - 6916, 2006.(PubMed : 16809296)(DOI: 10.1128/JVI.01900-05)
