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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2foy  sequence information (FASTA format)   
RELATED PDB ID1hcb, 2fov, 2foq, 2fos, 2fou
DescriptorCarbonic anhydrase 1 (E.C.4.2.1.1)
TitleHuman Carbonic Anhydrase I complexed with a two-prong inhibitor
Functional Keywordslyase, zinc, inhibitor, copper
LYASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00915] Cytoplasm
Organ source [UNP - P00915] Pancreas, and Spleen
Total number of polymer chains2
Total molecular weight60206.6 (the details in Structural Details Page)
AuthorsJude, K.M. , Banerjee, A.L. , Haldar, M.K. , Manokaran, S. , Roy, B. , Mallik, S. , Srivastava, D.K. , Christianson, D.W. (deposition date : 2006-01-14, release date : 2006-04-04)
Primary citationJude, K.M. , Banerjee, A.L. , Haldar, M.K. , Manokaran, S. , Roy, B. , Mallik, S. , Srivastava, D.K. , Christianson, D.W.
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128:3011 - 3018, 2006.(PubMed : 16506782)  (DOI: 10.1021/ja057257n)
Experimental methodX-RAY DIFFRACTION ( 1.55[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00915 ) , eF-site , KEGG ( EC 4.2.1.1 ) , PISA