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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2g8d  sequence information (FASTA format)   
RELATED PDB ID2g86, 2g89, 2g8a, 2g8m, 2g8o
Descriptorthymidylate synthase (E.C.2.1.1.45)
TitleLactobacillus casei thymidylate synthase Y261W-dUMP complex
Functional Keywordsbeta sheet, alpha/beta protein, methyltransferase, dUMP complex, active site mutation
TRANSFERASE
Biological sourceLactobacillus casei
Cellular location [UNP - P00469] Cytoplasm
Total number of polymer chains1
Total molecular weight36962.1 (the details in Structural Details Page)
AuthorsFiner-Moore, J.S. , Stroud, R.M. (deposition date : 2006-03-02, release date : 2006-03-14)
Primary citationNewby, Z. , Lee, T.T. , Morse, R.J. , Liu, Y. , Liu, L. , Venkatraman, P. , Santi, D.V. , Finer-Moore, J.S. , Stroud, R.M.
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261
Biochemistry, 45:7415 - 7428, 2006.(PubMed : 16768437)  (DOI: 10.1021/bi060152s)
Experimental methodX-RAY DIFFRACTION ( 2.40[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00469 ) , eF-site , KEGG ( EC 2.1.1.45 ) , PISA