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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2h8p  sequence information (FASTA format)   
DescriptorAntibody FAB fragment heavy chain, Antibody FAB fragment light chain, KcsA Channel
TitleStructure of a K channel with an amide to ester substitution in the selectivity filter
Functional KeywordsChannel, Semi-synthetic, Ester, MEMBRANE PROTEIN
Biological sourceMus musculus (house mouse)
Cellular location [UNP - P0A334] Cell membrane; Multi-pass membrane protein
Total number of polymer chains4
Total molecular weight58203 (the details in Structural Details Page)
AuthorsValiyaveetil, F.I. , MacKinnon, R. , Muir, T.W. (deposition date : 2006-06-07, release date : 2006-09-12)
Primary citationValiyaveetil, F.I. , Sekedat, M. , Mackinnon, R. , Muir, T.W.
Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128:11591 - 11599, 2006.(PubMed : 16939283)  (DOI: 10.1021/ja0631955)
Experimental methodX-RAY DIFFRACTION ( 2.25[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0A334 ) , eF-site , PISA