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MineSummary [2jbk]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID2jbk  sequence information (FASTA format)   
RELATED PDB ID1z8l, 2c6c, 2c6g, 2c6p, 2cij, 2jbj
DescriptorGLUTAMATE CARBOXYPEPTIDASE 2 (E.C.3.4.17.21)
TitleMEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH QUISQUALIC ACID (QUISQUALATE, ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID)
Functional KeywordsMULTIFUNCTIONAL ENZYME, NEURODEGENERATIVE DISEASE, GLYCOPROTEIN, METAL-BINDING, SIGNAL-ANCHOR, HYDROLASE, NAALADASE, DIPEPTIDASE, POLYMORPHISM, ZINC, PSMA, ANTIGEN, MEMBRANE, PROTEASE, PEPTIDASE, TRANSMEMBRANE, METAL- BINDING, METALLOPROTEASE, PROSTATE CANCER, CARBOXYPEPTIDASE,
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - Q04609] Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm
Organ sourceBRAIN
Total number of polymer chains5
Total molecular weight82696.4 (the details in Structural Details Page)
AuthorsMesters, J.R. , Henning, K. , Hilgenfeld, R. (deposition date : 2006-12-07, release date : 2006-12-18)
Primary citationMesters, J.R. , Henning, K. , Hilgenfeld, R.
Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63:508 - , 2007.(PubMed : 17372356)  (DOI: 10.1107/S090744490700902X)
Experimental methodX-RAY DIFFRACTION ( 2.99[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q04609 ) , eF-site , KEGG ( EC 3.4.17.21 ) , PISA