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MineSummary [2hrr]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2hrr  sequence information (FASTA format)   
DescriptorLiver carboxylesterase 1 (E.C.3.1.1.1)
TitleCrystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
Functional KeywordsHydrolase, Carboxylesterase, Tabun
Biological sourceHomo sapiens (human)
Cellular location [UNP - P23141] Endoplasmic reticulum lumen
Organ source [UNP - P23141] Liver
[UNP - P23141] Peripheral blood, and Placenta
[UNP - P23141] Macrophage
[UNP - P23141] Heart, and Oesophagus
[UNP - P23141] Blood, and Lung
[UNP - P23141] Brain
Total number of polymer chains3
Total molecular weight179528.9 (the details in Structural Details Page)
AuthorsFleming, C.D. , Redinbo, M.R. (deposition date : 2006-07-20, release date : 2007-05-01)
Primary citationFleming, C.D. , Edwards, C.C. , Kirby, S.D. , Maxwell, D.M. , Potter, P.M. , Cerasoli, D.M. , Redinbo, M.R.
Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46:5063 - 5071, 2007.(PubMed : 17407327)  (DOI: 10.1021/bi700246n)
Experimental methodX-RAY DIFFRACTION ( 2.70[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P23141 ) , eF-site , KEGG ( EC 3.1.1.1 ) , PISA