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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2jgw  sequence information (FASTA format)   
RELATED PDB ID1fhc, 1haq, 1hcc, 1hfh, 1hfi, 1kov, 2bzm, 2g7i, 2jgx
DescriptorCOMPLEMENT FACTOR H
TitleSTRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H - THE AMD AT RISK VARIENT (402H)
Functional KeywordsAGE RELATED MACULAR DEGENERATION, AGE-RELATED MACULAR DEGENERATION, DISEASE MUTATION, GLYCOSAMINOGLYCAN, ALTERNATIVE SPLICING, COMPLEMENT ALTERNATE PATHWAY, GLYCOPROTEIN, INNATE IMMUNITY, IMMUNE RESPONSE, SUSHI, FACTOR H, COMPLEMENT, POLYMORPHISM
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - P08603] Secreted
Organ source [UNP - P08603] Liver
[UNP - P08603] Testis, and Urinary bladder
[UNP - P08603] Plasma
Total number of polymer chains1
Total molecular weight6985.1 (the details in Structural Details Page)
AuthorsHerbert, A.P. , Deakin, J.A. , Schmidt, C.Q. , Blaum, B.S. , Egan, C. , Ferreira, V.P. , Pangburn, M.K. , Lyon, M. , Uhrin, D. , Barlow, P.N. (deposition date : 2007-02-16, release date : 2007-03-20)
Primary citationHerbert, A.P. , Deakin, J.A. , Schmidt, C.Q. , Blaum, B.S. , Egan, C. , Ferreira, V.P. , Pangburn, M.K. , Lyon, M. , Uhrin, D. , Barlow, P.N.
Structure Shows that a Glycosaminoglycan and Protein Recognition Site in Factor H is Perturbed by Age-Related Macular Degeneration-Linked Single Nucleotide Polymorphism.
J.Biol.Chem., 282:18960 - , 2007.(PubMed : 17360715)  (DOI: 10.1074/jbc.M609636200)
Experimental methodSOLUTION NMR
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P08603 ) , eF-site , PISA , NRG-CING