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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2pdi  sequence information (FASTA format)   
RELATED PDB ID2pd5, 2pd9, 2pdb, 2pdc, 2pdf, 2pdg, 2pdh, 2pdj, 2pdk, 2pdl, 2pdm, 2pdn, 2pdp, 2pdq, 2pdu, 2pdw, 2pdx, 2pdy
DescriptorAldose reductase (E.C.1.1.1.21)
TitleHuman aldose reductase mutant L300A complexed with zopolrestat at 1.55 A.
Functional KeywordsTIM barrel, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight37019.4 (the details in Structural Details Page)
AuthorsSteuber, H. , Heine, A. , Klebe, G. (deposition date : 2007-04-01, release date : 2008-04-01)
Primary citationSteuber, H. , Heine, A. , Podjarny, A. , Klebe, G.
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
J.Mol.Biol., 379:991 - 1016, 2008.(PubMed : 18495158)  (DOI: 10.1016/j.jmb.2008.03.063)
Experimental methodX-RAY DIFFRACTION ( 1.55[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA