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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2pgr  sequence information (FASTA format)   
RELATED PDB ID2qvn, 2pgf
Descriptoradenosine deaminase (E.C.3.5.4.4)
TitleCrystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin
Functional KeywordsMetallo-dependent hydrolase, Structural Genomics, Medical Structural Genomics of Pathogenic Protozoa Consortium, MSGPP, Structural Genomics of Pathogenic Protozoa Consortium, SGPP, PSI, Protein Structure Initiative
HYDROLASE
Biological sourcePlasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains1
Total molecular weight43893.6 (the details in Structural Details Page)
AuthorsLarson, E.T. , Merritt, E.A. , Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date : 2007-04-10, release date : 2007-04-24)
Primary citationLarson, E.T. , Deng, W. , Krumm, B.E. , Napuli, A. , Mueller, N. , Van Voorhis, W.C. , Buckner, F.S. , Fan, E. , Lauricella, A. , DeTitta, G. , Luft, J. , Zucker, F. , Hol, W.G. , Verlinde, C.L. , Merritt, E.A.
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381:975 - 988, 2008.(PubMed : 18602399)  (DOI: 10.1016/j.jmb.2008.06.048)
Experimental methodX-RAY DIFFRACTION ( 2.300[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( A5KE01 ) , eF-site , KEGG ( EC 3.5.4.4 ) , PISA