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MineSummary [2pob]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2pob  sequence information (FASTA format)   
DescriptorPeroxisome proliferator-activated receptor gamma
TitlePPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709
Functional KeywordsPPARG, Nuclear receptor,PPAR, Gene Regulation
Biological sourceHomo sapiens (human)
Cellular location [UNP - P37231] Nucleus
Organ source [UNP - P37231] Heart
[UNP - P37231] Adipose tissue
[UNP - P37231] Bone marrow
[UNP - P37231] Placenta
Total number of polymer chains2
Total molecular weight62854.6 (the details in Structural Details Page)
AuthorsNolte, R.T. (deposition date : 2007-04-26, release date : 2008-03-18)
Primary citationTrump, R.P. , Cobb, J.E. , Shearer, B.G. , Lambert, M.H. , Nolte, R.T. , Willson, T.M. , Buckholtz, R.G. , Zhao, S.M. , Leesnitzer, L.M. , Iannone, M.A. , Pearce, K.H. , Billin, A.N. , Hoekstra, W.J.
Cocrystal structure guided array synthesis of PPARgamma inverse agonists
BIOORG.MED.CHEM.LETT., 17:3916 - 3920, 2007.(PubMed : 17533125)  (DOI: doi:10.1016/j.bmcl.2007.04.111)
Experimental methodX-RAY DIFFRACTION ( 2.30[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P37231 ) , eF-site , PISA