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MineSummary [1daz]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1daz  sequence information (FASTA format)   
RELATED PDB ID1a94
DescriptorHIV-1 PROTEASE (RETROPEPSIN) (E.C.3.4.23.16)
TitleSTRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Functional KeywordsHIV-1 PROTEASE, MUTANT, DIMER, INHIBITOR, OCCUPANCY, HYDROLASE
Biological sourceHuman immunodeficiency virus 1
Cellular location [UNP - P03367] Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains4
Total molecular weight23117.6 (the details in Structural Details Page)
AuthorsMahalingam, B. , M Louis, J. , Reed, C.C. , Adomat, J.M. , Krouse, J. , Wang, Y.F. , W Harrison, R. , Weber, I.T. (deposition date : 1999-11-01, release date : 2000-05-03)
Primary citationMahalingam, B. , Louis, J.M. , Reed, C.C. , Adomat, J.M. , Krouse, J. , Wang, Y.F. , Harrison, R.W. , Weber, I.T.
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263:238 - 245, 1999.(PubMed : 10429209)  (DOI: 10.1046/j.1432-1327.1999.00514.x)
Experimental methodX-RAY DIFFRACTION ( 1.55[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P03367 ) , eF-site , KEGG ( EC 3.4.23.16 ) , PISA