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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2q5s  sequence information (FASTA format)   
RELATED PDB ID2q59, 2q5p, 2q61, 2q6r, 2q6s
DescriptorPeroxisome Proliferator-Activated Receptor gamma, ligand binding domain
TitleCrystal Structure of PPARgamma bound to partial agonist nTZDpa
Functional KeywordsProtein-ligand complex, Ligand binding protein
Biological sourceHomo sapiens (human)
Cellular location [UNP - P37231] Nucleus
Organ source [UNP - P37231] Heart
[UNP - P37231] Adipose tissue
[UNP - P37231] Bone marrow
[UNP - P37231] Placenta
Total number of polymer chains2
Total molecular weight63447.8 (the details in Structural Details Page)
AuthorsBruning, J.B. , Nettles, K.W. (deposition date : 2007-06-01, release date : 2007-10-23)
Primary citationBruning, J.B. , Chalmers, M.J. , Prasad, S. , Busby, S.A. , Kamenecka, T.M. , He, Y. , Nettles, K.W. , Griffin, P.R.
Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism
Structure, 15:1258 - 1271, 2007.(PubMed : 17937915)  (DOI: 10.1016/j.str.2007.07.014)
Experimental methodX-RAY DIFFRACTION ( 2.050[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P37231 ) , eF-site , PISA