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MineSummary [2q80]

[2q80] replaced from '2fvi'

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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PDB ID2q80  sequence information (FASTA format)   
DescriptorGeranylgeranyl pyrophosphate synthetase (E.C.2.5.1.1, 2.5.1.10, 2.5.1.29)
TitleCrystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP
Functional Keywordsisoprenoid pathway, isopentenyl transferase, Structural Genomics, Structural Genomics Consortium, SGC
TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - O95749] Cytoplasm
Organ source [UNP - O95749] Fetal heart
[UNP - O95749] Testis
[UNP - O95749] Pituitary
[UNP - O95749] Liver, and Spleen
[UNP - O95749] Kidney, and Testis
Total number of polymer chains6
Total molecular weight213013.2 (the details in Structural Details Page)
AuthorsKavanagh, K.L. , Dunford, J.E. , Bunkoczi, G. , Smee, C. , Vondelft, F. , Arrowsmith, C. , Weigelt, J. , Edwards, A. , Sundstrom, M. , Oppermann, U. , Structural Genomics Consortium (SGC) (deposition date : 2007-06-08, release date : 2007-06-19)
Primary citationKavanagh, K.L. , Dunford, J.E. , Bunkoczi, G. , Russell, R.G. , Oppermann, U.
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J.Biol.Chem., 281:22004 - 22012, 2006.(PubMed : 16698791)  (DOI: 10.1074/jbc.M602603200)
Experimental methodX-RAY DIFFRACTION ( 2.70[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( O95749 ) , eF-site , KEGG ( EC 2.5.1.1, 2.5.1.10, 2.5.1.29 ) , PISA