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<Asymmetric unit>
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( jV3 / Jmol ) *1
PDB ID2qcl  sequence information (FASTA format)   
RELATED PDB ID2v30, 2jgy
DescriptorUOrotidine 5'- phosphate decarboxylase (OMPdecase) (E.C.4.1.1.23)
TitleCrystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP
Functional KeywordsUMP synthase, decarboxylase, catalytic proficiency, Lyase
Biological sourceHomo sapiens (human)
Organ source [UNP - P11172] Leukocyte
[UNP - P11172] Colon adenocarcinoma
[UNP - P11172] Fetal brain
[UNP - P11172] Muscle
Total number of polymer chains2
Total molecular weight57426.3 (the details in Structural Details Page)
AuthorsWittmann, J. , Rudolph, M. (deposition date : 2007-06-19, release date : 2007-11-06)
Primary citationWittmann, J.G. , Heinrich, D. , Gasow, K. , Frey, A. , Diederichsen, U. , Rudolph, M.G.
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure, 16:82 - 92, 2008.(PubMed : 18184586)  (DOI: 10.1016/j.str.2007.10.020)
Experimental methodX-RAY DIFFRACTION ( 1.85[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P11172 ) , eF-site , KEGG ( EC 4.1.1.23 ) , PISA