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MineSummary [2qnq]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2qnq  sequence information (FASTA format)   
RELATED PDB ID2pqz, 2pwc, 2pwr, 2qnp, 2qnn
DescriptorGag-Pol polyprotein (Pr160Gag-Pol) (E.C.3.4.23.16)
TitleHIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor
Functional Keywordsprotein-ligand complex, AIDS, Aspartyl protease, Capsid maturation, Core protein, Cytoplasm, DNA integration, DNA recombination, DNA-directed DNA polymerase, Endonuclease, Hydrolase, Lipoprotein, Magnesium, Membrane, Metal-binding, Multifunctional enzyme, Myristate, Nuclease, Nucleotidyltransferase, Phosphorylation, Protease, RNA-binding, RNA-directed DNA polymerase, Transferase, Viral nucleoprotein, Virion, Zinc, Zinc-finger
HYDROLASE
Biological sourceHuman immunodeficiency virus 1
Cellular location [UNP - P03367] Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains2
Total molecular weight22344.7 (the details in Structural Details Page)
AuthorsBoettcher, J. , Blum, A. , Heine, A. , Diederich, W.E. , Klebe, G. (deposition date : 2007-07-19, release date : 2008-04-15)
Primary citationBlum, A. , Bottcher, J. , Heine, A. , Klebe, G. , Diederich, W.E.
Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold.
J.Med.Chem., 51:2078 - 2087, 2008.(PubMed : 18348517)  (DOI: 10.1021/jm701142s)
Experimental methodX-RAY DIFFRACTION ( 2.3[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P03367 ) , eF-site , KEGG ( EC 3.4.23.16 ) , PISA