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<Asymmetric unit>

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PDB ID2qu6  sequence information (FASTA format)   
RELATED PDB ID2qu5
DescriptorVascular endothelial growth factor receptor 2 (E.C.2.7.10.1)
TitleCrystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor
Functional Keywordsreceptor tyrosine kinase, KDR, Angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P35968] Membrane; Single-pass type I membrane protein
Organ source [UNP - P35968] Umbilical vein
[UNP - P35968] Lung
Total number of polymer chains2
Total molecular weight73681.9 (the details in Structural Details Page)
AuthorsWhittington, D.A. , Kim, J.L. , Long, A.M. , Rose, P. , Gu, Y. , Zhao, H. (deposition date : 2007-08-03, release date : 2007-09-25)
Primary citationPotashman, M.H. , Bready, J. , Coxon, A. , Demelfi, T.M. , Dipietro, L. , Doerr, N. , Elbaum, D. , Estrada, J. , Gallant, P. , Germain, J. , Gu, Y. , Harmange, J.C. , Kaufman, S.A. , Kendall, R. , Kim, J.L. , Kumar, G.N. , Long, A.M. , Neervannan, S. , Patel, V.F. , Polverino, A. , Rose, P. , Plas, S.V. , Whittington, D. , Zanon, R. , Zhao, H.
Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50:4351 - 4373, 2007.(PubMed : 17696416)  (DOI: 10.1021/jm070034i)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P35968 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA