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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2qx1  sequence information (FASTA format)   
RELATED PDB ID1u6s, 1hzp, 1u6e, 1hnj, 1hnk
DescriptorCrystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide
TitleCrystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide
Functional KeywordsFATTY ACID BIOSYNTHESIS, MYOBACTERIUM TUBERCULOSIS, STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY, ENZYME INHIBITOR COMPLEX, MECHANISM BASED INHIBITOR, Acyltransferase, Cytoplasm, Lipid synthesis, Multifunctional enzyme, Transferase
TRANSFERASE
Biological sourceMycobacterium tuberculosis
Cellular location [UNP - P0A574] Cytoplasm
Total number of polymer chains2
Total molecular weight70923.5 (the details in Structural Details Page)
AuthorsSachdeva, S. , Musayev, F. , Alhamadsheh, M. , Scarsdale, J.N. , Wright, H.T. , Reynolds, K.A. (deposition date : 2007-08-10, release date : 2008-03-18)
Primary citationSachdeva, S. , Musayev, F. , Alhamadsheh, M.M. , Neel Scarsdale, J. , Tonie Wright, H. , Reynolds, K.A.
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Bioorg.Chem., 36:85 - 90, 2008.(PubMed : 18096200)  (DOI: 10.1016/j.bioorg.2007.11.001)
Experimental methodX-RAY DIFFRACTION ( 2.60[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0A574 ) , eF-site , KEGG ( EC 2.3.1.41 ) , PISA