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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2v3h  sequence information (FASTA format)   
RELATED PDB ID1a2c, 1a3b, 1a3e, 1a46, 1a4w, 1a5g, 1a61, 1abi, 1abj, 1ad8, 1ae8, 1afe, 1aht, 1ai8, 1aix, 1awf, 1awh, 1ay6, 1b5g, 1b7x, 1ba8, 1bb0, 1bcu, 1bhx, 1bmm, 1bmn, 1bth, 1c1u, 1c1v, 1c1w, 1c4u, 1c4v, 1c4y, 1c5l, 1c5n, 1c5o, 1ca8, 1d3d, 1d3p, 1d3q, 1d3t, 1d4p, 1d6w, 1d9i, 1de7, 1dit, 1dm4, 1doj, 1dwb, 1dwc, 1dwd, 1dwe, 1dx5, 1e0f, 1eb1, 1eoj, 1eol, 1fpc, 1fph, 1g30, 1g32, 1g37, 1ghv, 1ghw, 1ghx, 1ghy, 1gj4, 1gj5, 1h8d, 1h8i, 1hag, 1hah, 1hai, 1hao, 1hap, 1hbt, 1hdt, 1hgt, 1hlt, 1hut, 1hxe, 1hxf, 1ihs, 1iht, 1jmo, 1jou, 1jwt, 1k21, 1k22, 1kts, 1ktt, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1mh0, 1mu6, 1mu8, 1mue, 1nm6, 1no9, 1nrn, 1nro, 1nrp, 1nrq, 1nrr, 1nrs, 1nt1, 1nu7, 1nu9, 1ny2, 1nzq, 1o0d, 1o2g, 1o5g, 1ook, 1oyt, 1p8v, 1ppb, 1qbv, 1qhr, 1qj1, 1qj6, 1qj7, 1qur, 1rd3, 1riw, 1sb1, 1sfq, 1sg8, 1sgi, 1shh, 1sl3, 1sr5, 1t4u, 1t4v, 1ta2, 1ta6, 1tb6, 1tbz, 1thp, 1thr, 1ths, 1tmb, 1tmt, 1tmu, 1tom, 1tq0, 1tq7, 1twx, 1uma, 1uvs, 1vr1, 1vzq, 1w7g, 1way, 1wbg, 1xm1, 1xmn, 1ype, 1ypg, 1ypj, 1ypk, 1ypl, 1ypm, 1z8i, 1z8j, 1zgi, 1zgv, 1zrb, 2a0q, 2afq, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 2cf8, 2cf9, 2cn0, 2gp9, 2hgt, 2hnt, 2hpp, 2hpq, 2jh0, 2jh5, 2jh6, 2thf, 2uuf, 2uuj, 2uuk, 3hat, 3htc, 4htc, 4thn, 5gds, 7kme, 8kme
DescriptorTHROMBIN HEAVY CHAIN (E.C.3.4.21.5), HIRUDIN IIA, THROMBIN LIGHT CHAIN (E.C.3.4.21.5)
TitleTHROMBIN WITH 3-CYCLE NO F
Functional KeywordsSERINE PROTEASE INHIBITOR COMPLEX, BLOOD CLOTTING, SERINE PROTEASE INHIBITOR, GAMMA-CARBOXYGLUTAMIC ACID, SERINE PROTEASE, CALCIUM-BINDING, DISEASE MUTATION, BLOOD COAGULATION, PROTEASE INHIBITOR, SULFATION, ACUTE PHASE, POLYMORPHISM, GLYCOPROTEIN, CLEAVAGE ON PAIR OF BASIC RESIDUES, KRINGLE, CALCIUM, ZYMOGEN, PROTEASE, HYDROLASE
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - P00734] Secreted, extracellular space
Organ source [UNP - P00734] Mammary gland
[UNP - P00734] Plasma
Total number of polymer chains3
Total molecular weight34802.2 (the details in Structural Details Page)
AuthorsBanner, D.W. , Obst, U. (deposition date : 2007-06-18, release date : 2008-06-24)
Primary citationMueller, K. , Faeh, C. , Diederich, F.
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
Science, 317:1881 - 1886, 2007.(PubMed : 17901324)  (DOI: 10.1126/science.1131943)
Experimental methodX-RAY DIFFRACTION ( 1.79[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00734, P28503 ) , eF-site , KEGG ( EC 3.4.21.5 ) , PISA