PDB ID 2uwo sequence information (FASTA format)
RELATED PDB ID 1c5m , 1ezq , 1f0r , 1f0s , 1fax , 1fjs , 1fxy , 1g2l , 1g2m , 1hcg , 1ioe , 1iqe , 1iqf , 1iqg , 1iqh , 1iqi , 1iqj , 1iqk , 1iql , 1iqm , 1iqn , 1ksn , 1kye , 1lpg , 1lpk , 1lpz , 1lqd , 1mq5 , 1mq6 , 1msx , 1nfu , 1nfw , 1nfx , 1nfy , 1nl8 , 1p0s , 1v3x , 1wu1 , 1xka , 1xkb , 1z6e , 2bmg , 2boh , 2bok , 2bq6 , 2bq7 , 2bqw , 2cji , 2fzz , 2g00 , 2gd4 , 2j2u , 2j34 , 2j38 , 2j4i , 2j94 , 2j95 , 2uwl , 2uwp
Descriptor COAGULATION FACTOR X (E.C.3.4.21.6)
Title SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA
Functional Keywords TARGET HOPPING, SERINE PROTEASE, EGF-LIKE DOMAIN, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE, BLOOD COAGULATION, GAMMA- CARBOXYGLUTAMIC ACID, CLEAVAGE ON PAIR OF BASIC RESIDUES
Biological source HOMO SAPIENS
(HUMAN)
Cellular location
[UNP - P00742 ]
Secreted
Organ source
[UNP - P00742 ]
OvaryUNP - P00742 ]
Liver
Total number of polymer chains 2
Total molecular weight 44223.7 (the details in Structural Details Page )
Authors Young, R.J. , Brown, D. , Burns-Kurtis, C.L. , Chan, C. , Convery, M.A. , Hubbard, J.A. , Kelly, H.A. , Pateman, A.J. , Patikis, A. , Senger, S. , Shah, G.P. , Toomey, J.R. , Watson, N.S. , Zhou, P.
(deposition date : 2007-03-22, release date : 2007-05-08)
Primary citation Young, R.J. , Brown, D. , Burns-Kurtis, C.L. , Chan, C. , Convery, M.A. , Hubbard, J.A. , Kelly, H.A. , Pateman, A.J. , Patikis, A. , Senger, S. , Shah, G.P. , Toomey, J.R. , Watson, N.S. , Zhou, P.Bioorg.Med.Chem.Lett. ,
17:2927 - , 2007.(PubMed : 17420122) (DOI: 10.1016/j.bmcl.2007.03.080)
Experimental method X-RAY DIFFRACTION ( 1.75[Å] )
Other Database Information
