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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3bbt  sequence information (FASTA format)   
RELATED PDB ID3bbw, 3bce
DescriptorReceptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1)
Titlecrystal structure of the ErbB4 kinase in complex with lapatinib
Functional Keywordsinactive kinase conformation, Alternative splicing, ATP-binding, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - Q15303] Membrane; Single-pass type I membrane protein
Organ source [UNP - Q15303] Mammary carcinoma
[UNP - Q15303] Fetal brain
[UNP - Q15303] Brain
Total number of polymer chains2
Total molecular weight76145.8 (the details in Structural Details Page)
AuthorsQiu, C. (deposition date : 2007-11-11, release date : 2008-02-12)
Primary citationQiu, C. , Tarrant, M.K. , Choi, S.H. , Sathyamurthy, A. , Bose, R. , Banjade, S. , Pal, A. , Bornmann, W.G. , Lemmon, M.A. , Cole, P.A. , Leahy, D.J.
Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16:460 - 467, 2008.(PubMed : 18334220)  (DOI: 10.1016/j.str.2007.12.016)
Experimental methodX-RAY DIFFRACTION ( 2.800[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q15303 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA