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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3bun  sequence information (FASTA format)   
RELATED PDB ID3bum, 3buo, 3buw, 3bux
Descriptor13-meric peptide from E3 ubiquitin-protein ligase CBL, Portein sprouty homolog 4 (E.C.6.3.2.-)
TitleCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
Functional KeywordsCbl, TKB, ligase, signal transduction, proto-oncogene, complex, Alternative splicing, Cytoplasm, Developmental protein, Membrane, Calcium, Metal-binding, Phosphoprotein, SH2 domain, Ubl conjugation pathway, Zinc, Zinc-finger, LIGASE/SIGNALING PROTEIN COMPLEX
Biological sourceHomo sapiens (human)
Cellular location [UNP - Q9C004] Cytoplasm
Organ source [UNP - Q9C004] Umbilical artery
[UNP - Q9C004] Brain
[UNP - P22681] Epithelium
[UNP - P22681] T-cell
Total number of polymer chains2
Total molecular weight39776 (the details in Structural Details Page)
AuthorsNg, C. , Jackson, R.A. , Buschdorf, J.P. , Sun, Q. , Guy, G.R. , Sivaraman, J. (deposition date : 2008-01-03, release date : 2008-02-26)
Primary citationNg, C. , Jackson, R.A. , Buschdorf, J.P. , Sun, Q. , Guy, G.R. , Sivaraman, J.
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27:804 - 816, 2008.(PubMed : 18273061)  (DOI: 10.1038/emboj.2008.18)
Experimental methodX-RAY DIFFRACTION ( 2.000[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q9C004, P22681 ) , eF-site , PISA