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MineSummary [3buv]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID3buv  sequence information (FASTA format)   
RELATED PDB ID3bur
Descriptor3-oxo-5-beta-steroid 4-dehydrogenase (E.C.1.3.1.3)
TitleCrystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A.
Functional Keywords5-beta-reductase; catalytic tetrad; E120; HEPES; NADP, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, Oxidoreductase, Steroid metabolism
OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P51857] Cytoplasm
Organ sourceLiver
Total number of polymer chains2
Total molecular weight76765.7 (the details in Structural Details Page)
AuthorsDi Costanzo, L. , Drury, J. , Penning, T.M. , Christianson, D.W. (deposition date : 2008-01-03, release date : 2008-04-01)
Primary citationDi Costanzo, L. , Drury, J.E. , Penning, T.M. , Christianson, D.W.
Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.
J.Biol.Chem., 283:16830 - 16839, 2008.(PubMed : 18407998)  (DOI: 10.1074/jbc.M801778200)
Experimental methodX-RAY DIFFRACTION ( 1.35[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P51857 ) , eF-site , KEGG ( EC 1.3.1.3 ) , PISA