PDB ID 3buw sequence information (FASTA format)
RELATED PDB ID 3bum , 3bun , 3buo , 3bux
Descriptor 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL (E.C.6.3.2.-)
Title Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
Functional Keywords Cbl, TKB, ligase, signal transduction, proto-oncogene, complex, Alternative splicing, ATP-binding, Host-virus interaction, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, SH2 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation, Calcium, Cytoplasm, Metal-binding, Ubl conjugation pathway, Zinc, Zinc-finger, LIGASE/SIGNALING PROTEIN COMPLEX
Biological source Homo sapiens
(human)
Cellular location
[UNP - P22681 ]
Cytoplasm
Organ source
[UNP - P43405 ]
Eye, and LymphUNP - P43405 ]
TonsilUNP - P43405 ]
PlateletUNP - P22681 ]
EpitheliumUNP - P22681 ]
T-cell
Total number of polymer chains 4
Total molecular weight 79472.2 (the details in Structural Details Page )
Authors Ng, C. , Jackson, R.A. , Buschdorf, J.P. , Sun, Q. , Guy, G.R. , Sivaraman, J.
(deposition date : 2008-01-03, release date : 2008-02-26)
Primary citation Ng, C. , Jackson, R.A. , Buschdorf, J.P. , Sun, Q. , Guy, G.R. , Sivaraman, J.Embo J. ,
27:804 - 816, 2008.(PubMed : 18273061) (DOI: 10.1038/emboj.2008.18)
Experimental method X-RAY DIFFRACTION ( 1.450[Å] )
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