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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3cdg  sequence information (FASTA format)   
DescriptorHLA class I histocompatibility antigen, alpha chain E, Beta-2-microglobulin, Natural killer cells antigen CD94, NKG2-A/NKG2-B type II integral membrane protein, leader peptide of HLA class I histocompatibility antigen, alpha chain G
TitleHuman CD94/NKG2A in complex with HLA-E
Functional KeywordsNK cell receptor, immunity, C-type lectin, MHC, Glycoprotein, Immune response, Membrane, MHC I, Polymorphism, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, Alternative splicing, Signal-anchor, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Cellular location [UNP - P13747] Membrane; Single-pass type I membrane protein
[UNP - P61769] Secreted
[UNP - Q13241] Membrane; Single-pass type II membrane protein
Organ source [UNP - P13747] Ovarian adenocarcinoma, and Pancreas
[UNP - P13747] Peripheral blood
[UNP - P61769] Dendritic cell
[UNP - P61769] Leukemia
[UNP - P61769] Trachea
[UNP - P61769] Eye, and Skin
[UNP - P61769] Urine
[UNP - Q13241] Blood
[UNP - Q13241] Placenta
[UNP - P26715] Blood, and Kidney
[UNP - P17693] Fetal eye
Total number of polymer chains10
Total molecular weight145511 (the details in Structural Details Page)
AuthorsPetrie, E.J. , Clements, C.S. , Lin, J. , Sullivan, L.C. , Johnson, D. , Huyton, T. , Heroux, A. , Hoare, H.L. , Beddoe, T. , Reid, H.H. , Wilce, M.C.J. , Brooks, A.G. , Rossjohn, J. (deposition date : 2008-02-26, release date : 2008-04-22)
Primary citationPetrie, E.J. , Clements, C.S. , Lin, J. , Sullivan, L.C. , Johnson, D. , Huyton, T. , Heroux, A. , Hoare, H.L. , Beddoe, T. , Reid, H.H. , Wilce, M.C.J. , Brooks, A.G. , Rossjohn, J.
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence
J.Exp.Med., 205:725 - 735, 2008.(PubMed : 18332182)  (DOI: 10.1084/jem.20072525)
Experimental methodX-RAY DIFFRACTION ( 3.400[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P13747, P61769, Q13241, P26715, P17693 ) , eF-site , PISA