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MineSummary [3ch6]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID3ch6  sequence information (FASTA format)   
DescriptorCorticosteroid 11-beta-dehydrogenase isozyme 1 (E.C.1.1.1.146)
TitleCrystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone
Functional Keywords11B-HSD1, sdr, dehydrogenase, hydroxysteroid, inhibitor, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P28845] Endoplasmic reticulum membrane; Single-pass type II membrane protein
Organ source [UNP - P28845] Testis
[UNP - P28845] Brain
Total number of polymer chains4
Total molecular weight129665.2 (the details in Structural Details Page)
AuthorsSheriff, S. (deposition date : 2008-03-07, release date : 2008-06-10)
Primary citationWang, H. , Ruan, Z. , Li, J.J. , Simpkins, L.M. , Smirk, R.A. , Wu, S.C. , Hutchins, R.D. , Nirschl, D.S. , Van Kirk, K. , Cooper, C.B. , Sutton, J.C. , Ma, Z. , Golla, R. , Seethala, R. , Salyan, M.E. , Nayeem, A. , Krystek, S.R. , Sheriff, S. , Camac, D.M. , Morin, P.E. , Carpenter, B. , Robl, J.A. , Zahler, R. , Gordon, D.A. , Hamann, L.G.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg.Med.Chem.Lett., 18:3168 - 3172, 2008.(PubMed : 18485702)  (DOI: 10.1016/j.bmcl.2008.04.069)
Experimental methodX-RAY DIFFRACTION ( 2.350[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P28845 ) , eF-site , KEGG ( EC 1.1.1.146 ) , PISA