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MineSummary [3cmf]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3cmf  sequence information (FASTA format)   
RELATED PDB ID3bur, 3cot
Descriptor3-oxo-5-beta-steroid 4-dehydrogenase
TitleCrystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A.
Functional KeywordsC-C double bond reduction, CORTISONE, AKR1D1, steroid, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, NADP, Oxidoreductase, Steroid metabolism
OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P51857] Cytoplasm
Organ source [UNP - P51857] Liver
[UNP - P51857] Mammary gland
Total number of polymer chains2
Total molecular weight81402.8 (the details in Structural Details Page)
AuthorsDi Costanzo, L. , Drury, J. , Penning, T.M. , Christianson, D.W. (deposition date : 2008-03-21, release date : 2008-04-08)
Primary citationDi Costanzo, L. , Drury, J.E. , Penning, T.M. , Christianson, D.W.
Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.
J.Biol.Chem., 283:16830 - 16839, 2008.(PubMed : 18407998)  (DOI: 10.1074/jbc.M801778200)
Experimental methodX-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P51857 ) , eF-site , KEGG ( EC 1.3.1.3 ) , PISA