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MineSummary [3ddf]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID3ddf  sequence information (FASTA format)   
RELATED PDB ID1hty, 1qwn, 2alw, 2f7o, 2f7p, 2f18, 2f1a, 2f1b, 3blb, 3bub, 3ddg
Descriptoralpha-mannosidase 2 (E.C.3.2.1.114)
TitleGOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one
Functional KeywordsGH38 Glycosidase, HYDROLASE
Biological sourceDrosophila melanogaster (fruit fly)
Cellular location [UNP - Q24451] Golgi apparatus membrane; Single-pass type II membrane protein
Organ source [UNP - Q24451] Head
Total number of polymer chains1
Total molecular weight120491.7 (the details in Structural Details Page)
AuthorsKuntz, D.A. , Rose, D.R. , Hoffman, D. (deposition date : 2008-06-05, release date : 2008-07-01)
Primary citationFiaux, H. , Kuntz, D.A. , Hoffman, D. , Janzer, R.C. , Gerber-Lemaire, S. , Rose, D.R. , Juillerat-Jeanneret, L.
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
Bioorg.Med.Chem., 16:7337 - 7346, 2008.(PubMed : 18599296)  (DOI: 10.1016/j.bmc.2008.06.021)
Experimental methodX-RAY DIFFRACTION ( 1.200[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q24451 ) , eF-site , KEGG ( EC 3.2.1.114 ) , PISA