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MineSummary [1drb]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
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PDB ID1drb  sequence information (FASTA format)   
DescriptorDIHYDROFOLATE REDUCTASE (DHFR) (E.C.1.5.1.3) MUTANT WITH ASP 27 REPLACED BY CYS (D27C)
TitleCRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Functional KeywordsOXIDOREDUCTASE
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight37129.1 (the details in Structural Details Page)
AuthorsDavid, C. , Kraut, J. (deposition date : 1991-11-06, release date : 1994-01-31)
Primary citationBystroff, C. , Kraut, J.
Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30:2227 - 2239, 1991.(PubMed : 1998681)  (DOI: 10.1021/bi00222a028)
Experimental methodX-RAY DIFFRACTION ( 1.96[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0ABQ4 ) , eF-site , KEGG ( EC 1.5.1.3 ) , PISA