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MineSummary [3ckh]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3ckh  sequence information (FASTA format)   
RELATED PDB ID1nuk, 2bba
DescriptorEphrin type-A receptor 4 (E.C.2.7.10.1)
TitleCrystal structure of Eph A4 receptor
Functional KeywordsEph receptor, ATP-binding, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Transferase, Transmembrane, Tyrosine-protein kinase
TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P54764] Membrane; Single-pass type I membrane protein
Organ source [UNP - P54764] Fetal brain
[UNP - P54764] Brain
[UNP - P54764] Lung
Total number of polymer chains2
Total molecular weight41691.6 (the details in Structural Details Page)
AuthorsShi, J.H. , Song, J.X. (deposition date : 2008-03-15, release date : 2008-09-23)
Primary citationQin, H. , Shi, J. , Noberini, R. , Pasquale, E.B. , Song, J.
Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor
J.Biol.Chem., 283:29473 - 29484, 2008.(PubMed : 18708347)  (DOI: 10.1074/jbc.M804114200)
Experimental methodX-RAY DIFFRACTION ( 2.800[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P54764 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA