English Statistics Help FAQ Contact Us
Download >>
Links

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

MineSummary [3dda]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

More images...
View in 3D molecule viewer
( jV3 / Jmol ) *1
PDB ID3dda  sequence information (FASTA format)   
RELATED PDB ID3bwi, 3c88, 3c89, 3c8a, 3c8b, 3ddb
DescriptorBotulinum neurotoxin A light chain (E.C.3.4.24.69), Synaptosomal-associated protein 25
TitleCrystal structure of the catalytic domain of Botulinum neurotoxin serotype a with a snap-25 peptide
Functional KeywordsBOTULINUM NEUROTOXIN TYPE A, BOTOX, CATALYTIC DOMAIN, ENDOPEPTIDASE, SYNTAXIN, BIO-WARFARE AGENT, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, TRANSMEMBRANE, ZINC, ENZYME-SUBSTRATE COMPLEX, Pharmaceutical, Alternative splicing, Cell junction, Coiled coil, Lipoprotein, Palmitate, Phosphoprotein, Synapse, Synaptosome
Biological sourceClostridium botulinum
Cellular location [UNP - A5HZZ9] Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted
[UNP - P60880] Cytoplasm, perinuclear region (By similarity)
Organ source [UNP - P60880] Fetal brain, and Temporal cortex
[UNP - P60880] Frontal cortex
[UNP - P60880] Skeletal muscle
[UNP - P60880] Amygdala, and Hippocampus
[UNP - P60880] Brain
[UNP - P60880] Eye
Total number of polymer chains2
Total molecular weight50311.7 (the details in Structural Details Page)
AuthorsKumaran, D. , Swaminathan, S. (deposition date : 2008-06-05, release date : 2008-09-16)
Primary citationKumaran, D. , Rawat, R. , Ahmed, S.A. , Swaminathan, S.
Substrate binding mode and its implication on drug design for botulinum neurotoxin A
Plos Pathog., 4:e1000165 - e1000165, 2008.(PubMed : 18818739)  (DOI: 10.1371/journal.ppat.1000165)
Experimental methodX-RAY DIFFRACTION ( 1.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( A5HZZ9, P60880 ) , eF-site , KEGG ( EC 3.4.24.69 ) , PISA