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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID3efj  sequence information (FASTA format)   
RELATED PDB ID3efk
DescriptorHepatocyte growth factor receptor (E.C.2.7.10.1)
TitleStructure of c-Met with pyrimidone inhibitor 7
Functional Keywordsc-Met, Alternative splicing, ATP-binding, Chromosomal rearrangement, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Biological sourceHomo sapiens (Human)
Cellular location [UNP - P08581] Membrane; Single-pass type I membrane protein
Total number of polymer chains2
Total molecular weight71689.4 (the details in Structural Details Page)
AuthorsD'Angelo, N. , Bellon, S. , Whittington, D. (deposition date : 2008-09-09, release date : 2008-10-07)
Primary citationD'Angelo, N.D. , Bellon, S.F. , Booker, S.K. , Cheng, Y. , Coxon, A. , Dominguez, C. , Fellows, I. , Hoffman, D. , Hungate, R. , Kaplan-Lefko, P. , Lee, M.R. , Li, C. , Liu, L. , Rainbeau, E. , Reider, P.J. , Rex, K. , Siegmund, A. , Sun, Y. , Tasker, A.S. , Xi, N. , Xu, S. , Yang, Y. , Zhang, Y. , Burgess, T.L. , Dussault, I. , Kim, T.S.
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51:5766 - 5779, 2008.(PubMed : 18763753)  (DOI: 10.1021/jm8006189)
Experimental methodX-RAY DIFFRACTION ( 2.60[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P08581 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA