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<Asymmetric unit>
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PDB ID1dwe  sequence information (FASTA format)   
DescriptorALPHA-THROMBIN (E.C.3.4.21.5) COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND D-PHE-PRO-ARG-CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP
TitleCRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Functional KeywordsHYDROLASE(SERINE PROTEINASE)
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00734] Secreted, extracellular space
Organ sourcePLASMA
Total number of polymer chains4
Total molecular weight35704 (the details in Structural Details Page)
AuthorsBanner, D.W. , Hadvary, P. (deposition date : 1992-08-19, release date : 1994-01-31)
Primary citationBanner, D.W. , Hadvary, P.
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
J.Biol.Chem., 266:20085 - 20093, 1991.(PubMed : 1939071)
Experimental methodX-RAY DIFFRACTION ( 3.0[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00734 ) , eF-site , KEGG ( EC 3.4.21.5 ) , PISA