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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3fde  sequence information (FASTA format)   
RELATED PDB ID2zo0, 2zo1, 2zo2, 3f8i, 3f8j
DescriptorE3 ubiquitin-protein ligase UHRF1/DNA complex (E.C.6.3.2.-)
TitleMouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution
Functional KeywordsSRA domain, base flipping, DNA CpG methylation, Cell cycle, Developmental protein, DNA damage, DNA repair, DNA-binding, Ligase, Metal-binding, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
LIGASE
Biological sourceMus musculus
Cellular location [UNP - Q8VDF2] Nucleus
Organ source [UNP - Q8VDF2] T lymphoblast
[UNP - Q8VDF2] Mammary tumor
[UNP - Q8VDF2] Small intestine
Total number of polymer chains6
Total molecular weight63971.6 (the details in Structural Details Page)
AuthorsHashimoto, H. , Horton, J.R. , Zhang, X. , Cheng, X. (deposition date : 2008-11-25, release date : 2009-01-06)
Primary citationHashimoto, H. , Horton, J.R. , Zhang, X. , Cheng, X.
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4:8 - 14, 2009.(PubMed : 19077538)
Experimental methodX-RAY DIFFRACTION ( 1.41[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q8VDF2 ) , eF-site , KEGG (EC 6.3.2.- ) , PISA