PDB ID 3fde sequence information (FASTA format)
RELATED PDB ID 2zo0 , 2zo1 , 2zo2 , 3f8i , 3f8j
Descriptor E3 ubiquitin-protein ligase UHRF1/DNA complex (E.C.6.3.2.-)
Title Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution
Functional Keywords SRA domain, base flipping, DNA CpG methylation, Cell cycle, Developmental protein, DNA damage, DNA repair, DNA-binding, Ligase, Metal-binding, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger LIGASE
Biological source Mus musculus
Cellular location
[UNP - Q8VDF2 ]
Nucleus
Organ source
[UNP - Q8VDF2 ]
T lymphoblast
[UNP - Q8VDF2 ]
Mammary tumor
[UNP - Q8VDF2 ]
Small intestine
Total number of polymer chains 6
Total molecular weight 63971.6 (the details in Structural Details Page )
Authors Hashimoto, H. , Horton, J.R. , Zhang, X. , Cheng, X.
(deposition date : 2008-11-25, release date : 2009-01-06)
Primary citation Hashimoto, H. , Horton, J.R. , Zhang, X. , Cheng, X. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics ,
4:8 - 14, 2009.(PubMed : 19077538)
Experimental method X-RAY DIFFRACTION ( 1.41[Å] )
Other Database Information