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MineSummary [2w2q]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2w2q  sequence information (FASTA format)   
RELATED PDB ID1f5y, 1n7d, 1i0u, 1d2j, 1hz8, 1f8z, 1ajj, 1ldl, 1ldr, 1ijq, 1hj7, 2w2m, 2w2o, 2fcw, 1lrx, 2w2n, 2w2p, 1xfe
DescriptorPROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
TitlePCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR
Functional KeywordsHYDROLASE/RECEPTOR, PCSK9, LDLR, PROPROTEIN CONVERTASE, LOW-DENSITY LIPOPROTEIN RECEPTOR, EGF, CARDIOVASCULAR DISEASE, FAMILIAL HYPERCHOLESTEROLEMIA, LIPID METABOLISM, SERINE PROTEASE, HYDROLASE, LIPID TRANSPORT, STEROID METABOLISM, RECEPTOR
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - Q8NBP7] Secreted
[UNP - P01130] Membrane; Single-pass type I membrane protein
Organ source [UNP - Q8NBP7] Teratocarcinoma
[UNP - Q8NBP7] Cerebellum
[UNP - Q8NBP7] Epithelium
[UNP - P01130] Liver
[UNP - P01130] Lymph
[UNP - P01130] Plasma
Total number of polymer chains3
Total molecular weight57986.9 (the details in Structural Details Page)
AuthorsBottomley, M.J. , Cirillo, A. , Orsatti, L. , Ruggeri, L. , Fisher, T.S. , Santoro, J.C. , Cummings, R.T. , Cubbon, R.M. , Lo Surdo, P. , Calzetta, A. , Noto, A. , Baysarowich, J. , Mattu, M. , Talamo, F. , De Francesco, R. , Sparrow, C.P. , Sitlani, A. , Carfi, A. (deposition date : 2008-11-03, release date : 2008-11-18)
Primary citationBottomley, M.J. , Cirillo, A. , Orsatti, L. , Ruggeri, L. , Fisher, T.S. , Santoro, J.C. , Cummings, R.T. , Cubbon, R.M. , Lo Surdo, P. , Calzetta, A. , Noto, A. , Baysarowich, J. , Mattu, M. , Talamo, F. , De Francesco, R. , Sparrow, C.P. , Sitlani, A. , Carfi, A.
Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284:1313 - 1323, 2009.(PubMed : 19001363)  (DOI: 10.1074/jbc.M808363200)
Experimental methodX-RAY DIFFRACTION ( 2.33[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q8NBP7, P01130 ) , eF-site , KEGG (EC 3.4.21.- ) , PISA