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MineSummary [1a8m]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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PDB ID1a8m  sequence information (FASTA format)   
DescriptorTUMOR NECROSIS FACTOR ALPHA
TitleTUMOR NECROSIS FACTOR ALPHA, R31D MUTANT
Functional KeywordsLYMPHOKINE, CYTOKINE, CYTOTOXIN
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01375] Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted
Organ source [UNP - P01375] Blood
[UNP - P01375] Prostatic carcinoma
Total number of polymer chains3
Total molecular weight51986.1 (the details in Structural Details Page)
AuthorsReed, C. , Fu, Z.-Q. , Wu, J. , Xue, Y.-N. , Harrison, R.W. , Chen, M.-J. , Weber, I.T. (deposition date : 1998-03-27, release date : 1998-06-17)
Primary citationReed, C. , Fu, Z.Q. , Wu, J. , Xue, Y.N. , Harrison, R.W. , Chen, M.J. , Weber, I.T.
Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.
Protein Eng., 10:1101 - 1107, 1997.(PubMed : 9488135)  (DOI: 10.1093/protein/10.10.1101)
Experimental methodX-RAY DIFFRACTION ( 2.3[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01375 ) , eF-site , PISA