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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2ws7  sequence information (FASTA format)   
RELATED PDB ID1hit, 2hho, 2c8q, 1tyl, 2c8r, 1t1k, 1aiy, 1xda, 1htv, 1mso, 1uz9, 1fub, 1tym, 1hui, 2vk0, 1vkt, 1hls, 2ceu, 1t1q, 1qj0, 1mhj, 1fu2, 1sjt, 1qiy, 1iog, 2vjz, 1ioh, 1trz, 1evr, 1ev3, 1rwe, 1os4, 1guj, 1ai0, 1sf1, 1jco, 1jca, 1zeg, 1os3, 1xgl, 1t0c, 1qiz, 1g7b, 2wby, 2aiy, 1ev6, 1q4v, 2hh4, 2h67, 4aiy, 1j73, 1k3m, 1mhi, 2wc0, 1kmf, 2hiu, 1xw7, 5aiy, 1g7a, 1znj, 1zeh, 1his, 1b9e, 3aiy, 1w8p, 1hiq, 1lph, 1efe, 1t1p, 1a7f, 1ben, 1lkq, 2ws0, 2ws4, 2ws1, 2ws6, 2wrx, 2wrw, 2wru, 2wrv
DescriptorINSULIN A CHAIN, INSULIN B CHAIN
TitleSEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN PROB26-DTI
Functional KeywordsCARBOHYDRATE METABOLISM, GLUCOSE METABOLISM, HORMONE, ANALOGUE, DIABETES MELLITUS
Biological source [UNP - P01308] Homo sapiens (Human)
Cellular location [UNP - P01308] Secreted
Organ source [UNP - P01308] Pancreas
[UNP - P01308] Blood
Total number of polymer chains12
Total molecular weight32705 (the details in Structural Details Page)
AuthorsBrzozowski, A.M. , Jiracek, J. , Zakova, L. , Antolikova, E. , Watson, C.J. , Turkenburg, J.P. , Dodson, G.G. (deposition date : 2009-09-03, release date : 2010-02-09)
Primary citationJiracek, J. , Zakova, L. , Antolikova, E. , Watson, C.J. , Turkenburg, J.P. , Dodson, G.G. , Brzozowski, A.M.
Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107:1966 - , 2010.  (DOI: 10.1073/PNAS.0911785107)
Experimental methodX-RAY DIFFRACTION ( 2.59[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01308 ) , eF-site , PISA