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MineSummary [3cv6]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3cv6  sequence information (FASTA format)   
DescriptorAldo-keto reductase family 1 member C21 (E.C.1.1.1.209)
TitleThe crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.
Functional KeywordsAldo-keto reductase, Hydroxysteroid Dehydrogenase, Ternary Complex, Hexestrol, Cytoplasm, Lipid metabolism, NADP, Oxidoreductase, Phosphoprotein, Steroid metabolism
OXIDOREDUCTASE
Biological sourceMus musculus (Mouse)
Cellular location [UNP - Q91WR5] Cytoplasm (By similarity)
Organ source [UNP - Q91WR5] Kidney
[UNP - Q91WR5] Embryo
[UNP - Q91WR5] Liver
Total number of polymer chains2
Total molecular weight76428.1 (the details in Structural Details Page)
AuthorsDhagat, U. , El-Kabbani, O. (deposition date : 2008-04-17, release date : 2009-03-03)
Primary citationDhagat, U. , Endo, S. , Mamiya, H. , Hara, A. , El-Kabbani, O.
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate
Acta Crystallogr.,Sect.D, 65:257 - 265, 2009.  (DOI: 10.1107/S0907444908044028)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q91WR5 ) , eF-site , KEGG ( EC 1.1.1.209 ) , PISA