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MineSummary [3f2p]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID3f2p  sequence information (FASTA format)   
RELATED PDB ID3f28, 8tln
DescriptorThermolysin (E.C.3.4.24.27)
TitleThermolysin inhibition
Functional Keywordsprotein fragment complex, Calcium, Hydrolase, Metal-binding, Metalloprotease, Protease, Secreted, Zinc, Zymogen
HYDROLASE
Biological sourceBacillus thermoproteolyticus
Cellular location [UNP - P00800] Secreted
Total number of polymer chains1
Total molecular weight34834.6 (the details in Structural Details Page)
AuthorsEnglert, L. , Heine, A. , Klebe, G. (deposition date : 2008-10-30, release date : 2009-11-17)
Primary citationEnglert, L. , Silber, K. , Steuber, H. , Brass, S. , Over, B. , Gerber, H.D. , Heine, A. , Diederich, W.E. , Klebe, G.
Fragment-Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition.
Chemmedchem, 5:930 - 940, 2010.(PubMed : 20394106)  (DOI: 10.1002/cmdc.201000084)
Experimental methodX-RAY DIFFRACTION ( 1.95[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00800 ) , eF-site , KEGG ( EC 3.4.24.27 ) , PISA