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<Asymmetric unit>
= <Biological unit>

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PDB ID3fi2  sequence information (FASTA format)   
RELATED PDB ID3fi3
DescriptorMitogen-activated protein kinase 10 (E.C.2.7.11.24)
TitleCrystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451
Functional KeywordsJNK3, protein-inhibitor complex, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Biological sourceHomo sapiens (human)
Cellular location [UNP - P53779] Cytoplasm
Organ source [UNP - P53779] Hippocampus
[UNP - P53779] Brain
Total number of polymer chains1
Total molecular weight41315.3 (the details in Structural Details Page)
AuthorsHabel, J.E. (deposition date : 2008-12-10, release date : 2009-03-03)
Primary citationKamenecka, T. , Habel, J. , Duckett, D. , Chen, W. , Ling, Y.Y. , Frackowiak, B. , Jiang, R. , Shin, Y. , Song, X. , LoGrasso, P.
Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.
J.Biol.Chem., 284:12853 - 12861, 2009.(PubMed : 19261605)  (DOI: 10.1074/jbc.M809430200)
Experimental methodX-RAY DIFFRACTION ( 2.28[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P53779 ) , eF-site , KEGG ( EC 2.7.11.24 ) , PISA