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MineSummary [3fqe]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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PDB ID3fqe  sequence information (FASTA format)   
RELATED PDB ID3fqh, 3fqs
DescriptorTyrosine-protein kinase SYK (E.C.2.7.10.2)
TitleCrystal structure of spleen tyrosine kinase complexed with YM193306
Functional KeywordsSYK, SPLEEN TYPROSINE KINASE, KINASE INHIBITOR, PYRIMIDINE-5-CARBOXAMIDE, Alternative splicing, ATP-binding, Host-virus interaction, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, SH2 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation
TRANSFERASE
Biological sourceHomo sapiens (Human)
Organ source [UNP - P43405] Eye, and Lymph
[UNP - P43405] Tonsil
[UNP - P43405] Platelet
Total number of polymer chains1
Total molecular weight34224.7 (the details in Structural Details Page)
AuthorsKuglstatter, A. , Villasenor, A.G. (deposition date : 2009-01-07, release date : 2009-03-10)
Primary citationVillasenor, A.G. , Kondru, R. , Ho, H. , Wang, S. , Papp, E. , Shaw, D. , Barnett, J.W. , Browner, M.F. , Kuglstatter, A.
Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.
Chem.Biol.Drug Des., 73:466 - 470, 2009.(PubMed : 19220318)  (DOI: 10.1111/j.1747-0285.2009.00785.x)
Experimental methodX-RAY DIFFRACTION ( 2.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P43405 ) , eF-site , KEGG ( EC 2.7.10.2 ) , PISA