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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID3frd  sequence information (FASTA format)   
RELATED PDB ID3fra, 3frb, 3fre, 3frf
DescriptorDihydrofolate reductase
TitleS. aureus DHFR complexed with NADPH and folate
Functional KeywordsS aureus DHFR, OXIDOREDUCTASE, NADP, One-carbon metabolism
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total molecular weight19331.7 (the details in Structural Details Page)
AuthorsOefner, C. , Dale-Glenn, E. (deposition date : 2009-01-08, release date : 2010-01-12)
Primary citationOefner, C. , Bandera, M. , Haldimann, A. , Laue, H. , Schulz, H. , Mukhija, S. , Parisi, S. , Weiss, L. , Lociuro, S. , Dale, G.E.
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63:687 - 698, 2009.(PubMed : 19211577)  (DOI: 10.1093/jac/dkp024)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0A017 ) , eF-site , KEGG ( EC 1.5.1.3 ) , PISA