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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID3ime  sequence information (FASTA format)   
RELATED PDB ID3cov, 3imc, 3img
DescriptorPantothenate synthetase (E.C.6.3.2.1)
TitleCrystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid
Functional KeywordsMycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, drug design, fragment-based, ATP-binding, Magnesium, Metal-binding, Nucleotide-binding
Ligase
Biological sourceMycobacterium tuberculosis
Cellular location [UNP - P0A5R0] Cytoplasm (Potential)
Total number of polymer chains2
Total molecular weight63743.4 (the details in Structural Details Page)
AuthorsCiulli, A. , Hung, A.W. , Silvestre, H.L. , Wen, S. , Blundell, T.L. , Abell, C. (deposition date : 2009-08-10, release date : 2009-10-13)
Primary citationHung, A.W. , Silvestre, H.L. , Wen, S. , Ciulli, A. , Blundell, T.L. , Abell, C.
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Angew.Chem.Int.Ed.Engl., 48:8452 - 8456, 2009.(PubMed : 19780086)  (DOI: 10.1002/anie.200903821)
Experimental methodX-RAY DIFFRACTION ( 2.39[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0A5R0 ) , eF-site , KEGG ( EC 6.3.2.1 ) , PISA