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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID3nlg  sequence information (FASTA format)   
RELATED PDB ID3nld, 3nle, 3nlf, 3nlh, 3nli, 3nlj, 3nlk, 3nlm, 3nln, 3nlo, 3nlp, 3nlq, 3nlr, 3nlt, 3nlu, 3nlv, 3nlw, 3nlx, 3nly, 3nlz, 3nm0
DescriptorNitric oxide synthase, endothelial (E.C.1.14.13.39)
TitleStructure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine
Functional Keywordsnitric oxide synthase, heme enzyme, substrate inhibitor, Oxidoreductase
Biological sourceBos taurus (bovine,cow,domestic cattle,domestic cow) (the details in Structural Details Page)
Cellular location [UNP - P29473] Cell membrane
Organ source [UNP - P29473] Aortic endothelium
Total number of polymer chains2
Total molecular weight102525.4 (the details in Structural Details Page)
AuthorsJi, H. , Delker, S.L. , Li, H. , Martasek, P. , Roman, L. , Poulos, T.L. , Silverman, R.B. (deposition date : 2010-06-21, release date : 2010-11-03)
Primary citationJi, H. , Delker, S.L. , Li, H. , Martasek, P. , Roman, L.J. , Poulos, T.L. , Silverman, R.B.
Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.
J.Med.Chem., 53:7804 - 7824, 2010.(PubMed : 20958055)  (DOI: 10.1021/jm100947x)
Experimental methodX-RAY DIFFRACTION ( 2.38[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P29473 ) , eF-site , KEGG ( EC 1.14.13.39 ) , PISA