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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID3odu  sequence information (FASTA format)   
RELATED PDB ID3oe0, 3oe6, 3oe8, 3oe9
DescriptorC-X-C chemokine receptor type 4, Lysozyme Chimera
TitleThe 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t
Functional KeywordsStructural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D, 7TM, G protein-coupled receptor, GPCR, Signal transduction, Hydrolase, Cancer, HIV-1 co-receptor, chemokine, CXCL12, SDF1, isothiourea, Chimera, T4L Fusion,, Membrane protein, Transmembrane, SINGNALING PROTEIN,HYDROLASE, SIGNALING PROTEIN,HYDROLASE
Biological sourceHomo Sapiens, Enterobacteria phage T4 (the details in Structural Details Page)
Cellular location [UNP - P61073] Cell membrane; Multi-pass membrane protein
Organ source [UNP - P61073] Lung
[UNP - P61073] Fetal brain
[UNP - P61073] Fetal spleen
[UNP - P61073] Monocyte
[UNP - P61073] Peripheral blood leukocyte
[UNP - P61073] Peripheral blood lymphocyte
[UNP - P61073] Neutrophil
[UNP - P61073] Colon
[UNP - P61073] Cervix carcinoma
Total number of polymer chains2
Total molecular weight118217.5 (the details in Structural Details Page)
AuthorsWu, B. , Mol, C.D. , Han, G.W. , Katritch, V. , Chien, E.Y.T. , Liu, W. , Cherezov, V. , Stevens, R.C. , Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (deposition date : 2010-08-11, release date : 2010-10-27)
Primary citationWu, B. , Chien, E.Y. , Mol, C.D. , Fenalti, G. , Liu, W. , Katritch, V. , Abagyan, R. , Brooun, A. , Wells, P. , Bi, F.C. , Hamel, D.J. , Kuhn, P. , Handel, T.M. , Cherezov, V. , Stevens, R.C.
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330:1066 - 1071, 2010.(PubMed : 20929726)  (DOI: 10.1126/science.1194396)
Experimental methodX-RAY DIFFRACTION ( 2.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P61073, P00720 ) , eF-site , KEGG ( EC 3.2.1.17 ) , PISA