PDB ID 1ev2 sequence information (FASTA format)
RELATED PDB ID 1cvs , 1evt
Descriptor CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Title CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Functional Keywords IMMUNOGLOBULIN (IG)LIKE DOMAINS BELONGING TO THE I-SET SUBGROUP WITHIN IG-LIKE DOMAINS, B-TREFOIL FOLD, GROWTH FACTOR/GROWTH FACTOR RECEPTOR COMPLEX
Biological source Homo sapiens
(human)
Cellular location
[UNP - P21802 ]
Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted
Organ source
[UNP - P21802 ]
Neonatal brain stem
[UNP - P21802 ]
Stomach cancer
[UNP - P21802 ]
Placenta
[UNP - P21802 ]
Mammary gland
[UNP - P21802 ]
Cornea, and Mammary gland
[UNP - P21802 ]
Blood
[UNP - P21802 ]
Brain
Total number of polymer chains 8
Total molecular weight 159390.8 (the details in Structural Details Page )
Authors Plotnikov, A.N. , Hubbard, S.R. , Schlessinger, J. , Mohammadi, M.
(deposition date : 2000-04-19, release date : 2000-05-31)
Primary citation Plotnikov, A.N. , Hubbard, S.R. , Schlessinger, J. , Mohammadi, M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.) ,
101:413 - 424, 2000.(PubMed : 10830168) (DOI: 10.1016/S0092-8674(00)80851-X)
Experimental method X-RAY DIFFRACTION ( 2.20[Å] )
Other Database Information