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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2b4g  sequence information (FASTA format)   
Descriptordihydroorotate dehydrogenase (E.C.1.3.99.11)
Titledihydroorotate dehydrogenase
Functional KeywordsSTRUCTURAL GENOMICS, PSI, Protein Structure Initiative, Structural Genomics of Pathogenic Protozoa Consortium, SGPP, OXIDOREDUCTASE
Biological sourceTrypanosoma brucei
Total number of polymer chains4
Total molecular weight141592.5 (the details in Structural Details Page)
AuthorsArakaki, T.L. , Merritt, E.A. , Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date : 2005-09-23, release date : 2005-10-11)
Primary citationArakaki, T.L. , Buckner, F.S. , Gillespie, J.R. , Malmquist, N.A. , Phillips, M.A. , Kalyuzhniy, O. , Luft, J.R. , Detitta, G.T. , Verlinde, C.L. , Van Voorhis, W.C. , Hol, W.G. , Merritt, E.A.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68:37 - 50, 2008.(PubMed : 18312275)  (DOI: 10.1111/j.1365-2958.2008.06131.x)
Experimental methodX-RAY DIFFRACTION ( 1.95[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q57U83 ) , eF-site , KEGG ( EC 1.3.99.11 ) , PISA