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MineSummary [1fo3]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1fo3  sequence information (FASTA format)   
RELATED PDB ID1fmi, 1fo2
DescriptorALPHA1,2-MANNOSIDASE(E.C.3.2.1.24) COMPLEX WITH KIFUNENSINE
TitleCRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE
Functional Keywordsalpha-alpha7 barrel, HYDROLASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - Q9UKM7] Endoplasmic reticulum membrane; Single-pass type II membrane protein
Organ source [UNP - Q9UKM7] Fetal brain, Liver, Placenta, and Testis
[UNP - Q9UKM7] Lung, and Placenta
Total number of polymer chains1
Total molecular weight53343.1 (the details in Structural Details Page)
AuthorsVallee, F. , Karaveg, K. , Moremen, K.W. , Herscovics, A. , Howell, P.L. (deposition date : 2000-08-24, release date : 2001-01-17)
Primary citationVallee, F. , Karaveg, K. , Herscovics, A. , Moremen, K.W. , Howell, P.L.
Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
J.Biol.Chem., 275:41287 - 41298, 2000.(PubMed : 10995765)  (DOI: 10.1074/jbc.M006927200)
Experimental methodX-RAY DIFFRACTION ( 1.75[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q9UKM7 ) , eF-site , KEGG ( EC 3.2.1.24 ) , PISA