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MineSummary [1foe]

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PDB ID1foe  sequence information (FASTA format)   
DescriptorT-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1/RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE COMPLEX
TitleCRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Functional KeywordsDBL HOMOLOGY DOMAIN, PLECKSTRIN HOMOLOGY DOMAIN, GTPASE, GUANINE NUCLEOTIDE EXCHANGE FACTOR, signaling protein, immune system/signaling protein COMPLEX
Biological sourceMus musculus (house mouse) ,Homo sapiens (human) (the details in Structural Details Page)
Cellular location [UNP - P63000] Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity)
Organ source [UNP - Q60610] Brain
[UNP - Q60610] Mast cell
[UNP - P63000] Colon, and Skin
[UNP - P63000] Pancreas, and Skin
Total number of polymer chains8
Total molecular weight254540 (the details in Structural Details Page)
AuthorsWorthylake, D.K. , Rossman, K.L. , Sondek, J. (deposition date : 2000-08-27, release date : 2001-01-17)
Primary citationWorthylake, D.K. , Rossman, K.L. , Sondek, J.
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408:682 - 688, 2000.(PubMed : 11130063)  (DOI: 10.1038/35047014)
Experimental methodX-RAY DIFFRACTION ( 2.8[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q60610, P63000 ) , eF-site , PISA